Research publications (selection)



Gencer S, Döring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Müller M, Peters LJ, Megens RT, Aslani M, Von Hundelshausen P, Duchence J, Lemnitzer P, Soehnlein O, Weber C, Van der Vorst EPEndothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Research in Cardiology. 2022 Jun; 117(1):30


Peters LJ, Baaten CC, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andres D, Jankowski J, Biessen EA, Döring Y, Heemskerk JW, Weber C, Kuipers MJ, Van der Vorst EPMicroRNA-26b attenuates platelet adhesion and aggregation in mice. Biomedicines. 2022 Apr; 10(5):983



Sundararaman SS, Peters LJ, Nazir S, Bonnin Marquez A, Bouma JE, Bayasgalan S, Döring Y, Van der Vorst EP. PCSK9 imperceptibly affects chemokine receptor expression in vitro and in vivo.
International Journal Molecular Science. 2021 Dec; 22(23):13026


Van der Vorst EP*, Pepe MA*, Peters LJ, Haberbosch M, Jansen Y, Nauman R, Stathopoulos GT, Weber C, Bidzhekov K. Transcriptome signature of miRNA-16b KO mouse model suggests novel targets. BMC Genomic Data. 2021 Jun; 22(1):23


Sundararaman SS, Peters LJ, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EA, Jankowski J, Weber C, Döring Y, Van der Vorst EPAdipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe-/- mice. Scientific Reports. 2021 May; 11(1):10409


Gencer S, Döring Y, Jansen Y, Bayasgalan S, Schengel O, Müller M, Peters LJ, Weber C, Van der Vorst EPAdipocyte-specific ACKR3 regulates lipid levels in adipose tissue. Biomedicines. 2021 Apr; 9(4):394



Döring Y, Jansen Y, Cimen I, Aslani M, Gencer S, Peters LJ, Duchene J, Weber C*, Van der Vorst EP*. B-cell specific CXCR4 protects against atherosclerosis development and increases plasma IgM levels. Circulation Research. 2020 Mar; 126(6): 787-788


Van der Vorst EP, Daissormont I, Aslani M, Seijkens T, Wijnands E, Lutgens E, Duchene J, Santovito D, Döring Y, Halvorsen B, Aukrust P, Weber C, Höpken UE, Biessen EA. Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development. Thombosis & Heamostasis. 2020 Feb; 120(2): 344-347



Kiouptsi K, Jäckel S, Pontarollo G, Grill A, Kuijpers MJ, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JW, Van der Vorst EP*, Döring Y*, Reinhardt C*. The microbiota promotes arterial thrombosis in low-density lipoprotein receptor-deficient mice. mBio. 2019 Oct; 10(5): e02298-19


Van der Vorst EP*, Döring Y*, Duchene J, Jansen Y, Gencer S, Bidzhekov K, Atzler D, Santovito D, Rader DJ, Saleheen D, Weber C. CXCL12 derived from endothelial cells promotes atherosclerosis to drive coronary artery disease. Circulation. 2019 Mar; 139(10): 1338-1340


Van der Vorst EP*, Mandl M*, Müller M, Neideck C, Jansen Y, Hristov M, Gencer S, Peters LJ, Meiler S, Feld M, Geiselhöringer AL, De Jong RJ, Ohnmacht C, Noels H, Soehnlein O, Drechsler M, Weber C, Döring Y. Hematopoietic ChemR23 (Chemerin Receptor 23) fuels atherosclerosis by sustaining an M1 macrophage-phenotype and guidance of plasmacytoid dendritic cells to murine lesions. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Apr; 39(4): 685-693


Until 2018

Van der Vorst EP*, Theodorou K*, Gijbels MJ, Wolfs IM, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EA, Donners MM. Hematopoietic ADAM8 deficiency does not influence atherosclerotic plaque area or composition, despite its upregulation during plaque progression. Scientific Reports. 2017 Sep; 7(1)


Van der Vorst EP*, Rademakers T*, Daissormont IT*, Otten JJ, Theelen TL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Scientific Reports. 2017 Mar; 7


Van der Vorst EP*, Zhao Z*, Rami M, Holdt LM, Teupser D, Steffens S#, Weber C#. Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thrombosis & Heamostasis. 2017 Feb; 117(3): 644-646


Van der Vorst EP*, Theodorou K*, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LF, Tas SW, Wolfs IM, Kuijpers MJ, Gijbels MJ, Schalkwijk CG, Koonen, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, De Winther MP, Biessen EA, Donners MM. High Density Lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-κB/STAT1-IRF1 activation. Cell Metabolism. 2017 Jan; 25(1): 197-207


Van der Vorst EP, Wolfs IM, Jeurissen M, Keijbeck A, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Dreymueller D, Hamers AA, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM. Myeloid A Disintegrin and Metalloproteinase Domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
American Journal of Pathology. 2015 Apr; 185(4): 1145-1155


Van der Vorst EP*, Vanags LZ*, Dunn LL, Prosser HC, Rye KA, Bursill CA. High-Density Lipoproteins Suppress Chemokine Expression and Proliferation in Human Vascular Smooth Muscle Cells.
FASEB Journal. 2013 Apr; 27(4): 1413-1425


*denotes shared authorship



Van der Vorst EP, Lecour S. Finding the culprit for the failure of the immune clock as time goes by. Cardiovascular Research. 2022 Sep; 6:cvac146


Bonnin Marquez A, Van der Vorst EP, Maas SLKey chemokine pathways in atherosclerosis and their therapeutic potential. Journal of Clinical Medicine. 2021 Aug; 10(17):3825


Sundararaman SS, Döring Y, Van der Vorst EPPCSK9: a multi-faceted protein that is involved in cardiovascular biology. Biomedicines. 2021 Jul; 9(7):793


Peters LJ, Jans A, Bartneck M, Van der Vorst EPImmunomodulatory nanomedicine for the treatment of atherosclerosis. Journal of Clinical Medicine. 2021 Jul; 10(14):3185


Sundararaman SS, Van der Vorst EPCalcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health. International Journal Molecular Science. 2021 Mar; 22(5):2478


Bonnin Márquez B, Nazir S, Van der Vorst EPHigh-density Lipoprotein modifications: A pathological consequence or cause of disease progression? Biomedicines. 2020 Nov; 8(12)


Nazir S, Jankowski V, Bender G, Zewinger S, Rye KA, Van der Vorst EPInteraction between high-density lipoproteins and inflammation: Function matters more than concentration!
Advanced Drug Delivery Reviews. 2020 Oct; 159: 94-119


Peters LJ, Floege J, Biessen EA, Jankowski J, Van der Vorst EPMicroRNAs in chronic kidney disease: Four candidates for clinical application. International Journal Molecular Science. 2020 Sep; 21(18)


Peters LJ, Biessen EA, Hohl M, Weber C, Van der Vorst EP*, Santovito D*. Small thing matter: relevance of microRNAs in cardiovascular disease. Frontiers in Physiology. 2020 Jul; 11